Isobutylamine → HCID 21430469, compound

HRID 437165Notes

Reaction equation

HRID 437165 reaction equation
Cl.[CH3:2][N:3]([CH3:23])[S:4]([C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=1[N:16]1[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]1)[C:10](Cl)=[O:11])(=[O:6])=[O:5].[CH2:24]([NH2:28])[CH:25]([CH3:27])[CH3:26]>O1CCCC1>[CH2:24]([NH:28][C:10](=[O:11])[C:9]1[CH:13]=[CH:14][C:15]([N:16]2[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]2)=[C:7]([S:4](=[O:6])(=[O:5])[N:3]([CH3:23])[CH3:2])[CH:8]=1)[CH:25]([CH3:27])[CH3:26]

Participants

4

Reactant 2

HCID 6558IsobutylamineHCID 21430472HCID 21430472, compound

Product 1

HCID 21430469HCID 21430469, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

40 Grams of 3-dimethylsulfamoyl-4-(4-methylpiperazine-1-yl)-benzoylchloride-hydrochloride (0.1 mole) were introduced portionwise, while stirring, into a solution of 30 g of isobutylamine in 0.4 l of tetrahydrofurane. The mixture, whose temperature rose to about 50° C., was subsequently heated for another 10 minutes under reflux and was then concentrated to half its volume.

Workup

  1. customrose to about 50° C.
  2. temperaturewas subsequently heated for another 10 minutes
  3. temperatureunder reflux
  4. concentrationwas then concentrated to half its volume

Sources & evidence

ORD record
ord-93232c4ca5b74c49a3b5424574593d6e
Source dataset
uspto-grants-1977_06
Patent number
US04029787

Reaction notes

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