Water → HCID 21430434, compound

HRID 437166Notes

Reaction equation

HRID 437166 reaction equation
Cl[C:2]1C=[C:8]([Cl:10])[C:5](C#N)=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12].[O:15]1[CH2:20][CH2:19]OCC1.[CH3:21][N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1.[OH2:28]>>[Cl:10][C:8]1[C:19]([C:20]([OH:15])=[O:28])=[CH:2][C:3]([S:11](=[O:13])(=[O:14])[NH2:12])=[C:4]([N:25]2[CH2:26][CH2:27][N:22]([CH3:21])[CH2:23][CH2:24]2)[CH:5]=1

Participants

5

Reactant 4

HCID 962WaterHCID 312751,4-DioxaneHCID 531671-MethylpiperazineHCID 21430435HCID 21430435, compound

Product 1

HCID 21430434HCID 21430434, compound

Conditions

Temperature
100 °C

Procedure

A mixture of 50 g of 4,6-dichloro-3-sulfamoylbenzonitrile, 0.1 l of dioxane and 21 g of N-methylpiperazine was stirred for 2 hours at 100° C. Subsequently, the reaction solution was introduced into 0.3 l of water, the crystalline precipitate was suction-filtered, washed with water and recrystallized from ethanol.

Workup

  1. filtrationthe crystalline precipitate was suction-filtered
  2. washwashed with water
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-e8ad8e0a92644bfa9c741e5608499827
Source dataset
uspto-grants-1977_06
Patent number
US04029787

Reaction notes

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