HCID 21430443, compound → HCID 21430467, compound

HRID 437172Notes

Reaction equation

HRID 437172 reaction equation
[ClH:1].[CH2:2]([NH:5][S:6]([C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][C:17]=1[N:18]1[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]1)[C:12]([OH:14])=[O:13])(=[O:8])=[O:7])[CH:3]=[CH2:4].[H][H]>O1CCCC1.[Pd]>[ClH:1].[CH3:24][N:21]1[CH2:22][CH2:23][N:18]([C:17]2[CH:16]=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]=2[S:6](=[O:8])(=[O:7])[NH:5][CH2:2][CH2:3][CH3:4])[CH2:19][CH2:20]1

Participants

5

Reactant 2

HCID 21430443HCID 21430443, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21430467HCID 21430467, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

37.6 Grams of 3-allylsulfamoyl-4-(4-methylpiperazine-1-yl)-benzoic acid-hydrochloride (0.1 mole), prepared according to Example 32, were dissolved in 0.3 l of tetrahydrofurane and were hydrogentated in the presence of palladium black at 30° C. and at 40 atmospheres until no more hydrogen was absorbed. Subsequently the catalyst was separated, the solution was evaporated, and the residue was recrystallized from water.

Workup

  1. customwas absorbed
  2. customSubsequently the catalyst was separated
  3. customthe solution was evaporated
  4. customthe residue was recrystallized from water

Sources & evidence

ORD record
ord-2afb6eeea219435e8f83986d1045b7fa
Source dataset
uspto-grants-1977_06
Patent number
US04029787

Reaction notes

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