1,3-Benzodioxole-5-carbonyl chloride → 2-(3,4-Dimethoxyphenyl)ethyl-4-piperonylamidopiperidine

HRID 437216Notes

Reaction equation

HRID 437216 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([NH:19][C:20](=[O:27])[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:15][CH2:14]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].C([Cl:39])(=O)C1C=CC2[O:34][CH2:33][O:32]C=2C=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][N:13]2[CH2:14][CH2:15][CH:16]([NH:19][C:20](=[O:27])[C:21]3[CH:22]=[CH:23][C:24]4[O:34][CH2:33][O:32][C:25]=4[CH:26]=3)[CH2:17][CH2:18]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[OH2:2].[OH2:2].[ClH:39]

Participants

4

Reactant 2

HCID 27347491,3-Benzodioxole-5-carbonyl chlorideHCID 21413257N-{1-[2-(3,4-dimethoxyphenyl)ethyl]-4-piperidinyl}benzamide

Product 2

HCID 214306362-(3,4-Dimethoxyphenyl)ethyl-4-piperonylamidopiperidineHCID 21899424Dihydrate;hydrochloride

Procedure

The title compound hydrochloride dihydrate (m.p. 285°-8° C.) was prepared in the same way as for the compound of Example 5 but utilising piperonyloyl chloride in place of benzoyl chloride. (Found: C, 57.1; H, 6.8; N, 5.7. C23H28N2O5.HCl.2H2O requires C, 57.0; H, 6.8; N, 5.8%).

Sources & evidence

ORD record
ord-4cb6a7e44a744ce4b2922d4502196685
Source dataset
uspto-grants-1977_06
Patent number
US04029801

Reaction notes

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