HCID 10089254, compound → 4-Amino-1-(4-phenyl-4-oxobutyl)piperidine

HRID 437251Notes

Reaction equation

HRID 437251 reaction equation
C([NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:20])[CH2:12][CH2:11]1)(=O)C1C=CC=CC=1>Cl>[NH2:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][C:19]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[O:20])[CH2:12][CH2:11]1

Participants

3

Reactant 1

HCID 10089254HCID 10089254, compound

Product 1

HCID 126085374-Amino-1-(4-phenyl-4-oxobutyl)piperidine

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

4-Benzamido-1-(4-phenyl-4-oxobutyl)piperidine (0.5 g.) was suspended in 6 N HCl (10 ml.) and boiled for 8 hr. The solution was cooled, filtered (to remove benzoic acid) and the filtrate basified with potassium carbonate. The oil which separated was extracted into chloroform which on evaporation gave the title compound as the free base (0.30 g.). This was dissolved in ethanol, ethanol/HCl added until acid and the title compound filtered off (0.376 g.) as the dihydrochloride m.p. 269.7°.

Workup

  1. temperatureThe solution was cooled
  2. filtrationfiltered
  3. custom(to remove benzoic acid)
  4. customThe oil which separated
  5. extractionwas extracted into chloroform which on evaporation

Sources & evidence

ORD record
ord-654f273f789b41ac87b24d510cc01bbf
Source dataset
uspto-grants-1977_06
Patent number
US04029801

Reaction notes

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