反应详情

4-Amino-1-(4-phenyl-4-oxobutyl)piperidine dihydrochloride (3.19 g.) was acylated with p-chloro-benzoyl chloride (1.75 g.) in the manner of example 75. Filtration afforded the title compound as the base (3.277 g.). This was suspended in boiling ethanol (15 ml.) and ethanol/HCl added until acid. On cooling the title compound crystallised out as the hydrochloride, colourless needles (3.41 g.), m.p. 261.1°.

1. filtrationFiltration