Methyl iodide → HCID 21430644, compound

HRID 437255Notes

Reaction equation

HRID 437255 reaction equation
[C:1]([NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:20])[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I:27][CH3:28]>CN(C)C=O>[I-:27].[C:1]([NH:9][CH:10]1[CH2:15][CH2:14][N+:13]([CH3:28])([CH2:16][CH2:17][CH2:18][C:19]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[O:20])[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 100892541-(3-Benzoylpropyl)-4-benzamidopiperidine

Product 1

HCID 21430644HCID 21430644, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 4-benzamido-1-(4-phenyl-4-oxobutyl)-piperidine (1.75 g., 0.005 mole) and iodomethane (7.10 g., 0.05 mole) in N,N-dimethylformamide (5 ml.) was stirred for 150 hours at room temperature. The reaction mixture was filtered and the residue was washed with fresh N,N-dimethylformamide and then diethyl ether.

Workup

  1. filtrationThe reaction mixture was filtered
  2. washthe residue was washed with fresh N,N-dimethylformamide

Sources & evidence

ORD record
ord-4df8f3b8728146fbb9df3123a9427622
Source dataset
uspto-grants-1977_06
Patent number
US04029801

Reaction notes

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