Potassium Carbonate → HCID 21430140, compound

HRID 437263Notes

Reaction equation

HRID 437263 reaction equation
[CH2:1]([C:8]([C:10]1[CH:15]=[C:14]([OH:16])[CH:13]=[CH:12][C:11]=1[OH:17])=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18](Br)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH:25]([CH3:27])[CH3:26].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:1]([C:8]([C:10]1[CH:15]=[C:14]([O:16][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH:25]([CH3:27])[CH3:26])[CH:13]=[CH:12][C:11]=1[OH:17])=[O:9])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 128239201-(2,5-Dihydroxyphenyl)-2-phenylethan-1-oneHCID 143129061-Bromo-8-methylnonane

Product 1

HCID 21430140HCID 21430140, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
20 °C

Procedure

A mixture of 40.1 parts of 2,5-dihydroxyphenyl benzyl ketone, 42.7 parts of isodecylbromide, 48.5 parts of potassium carbonate and 400 parts of dry acetone was stirred under reflux for 120 hours. On cooling to 20° C the inorganic salts were filtered off and the acetone filtrates evaporated to give a brown oil. This residue was dissolved in 200 parts of petroleum ether, filtered to remove insoluble matter, and then washed with 4 × 50 parts of N sodium hydroxide solution and finally with water. The petrol solution was dried and evaporated to yield 42.4 parts of 2-hydroxy-5-isodecyloxyphenyl benzyl ketone as a brown oil.

Workup

  1. temperatureunder reflux for 120 hours
  2. filtrationwere filtered off
  3. customthe acetone filtrates evaporated
  4. customto give a brown oil
  5. filtrationfiltered
  6. customto remove insoluble matter
  7. washwashed with 4 × 50 parts of N sodium hydroxide solution and finally with water
  8. dry with materialThe petrol solution was dried
  9. customevaporated

Sources & evidence

ORD record
ord-b2732b1b2ab54ae0b849d3af76724830
Source dataset
uspto-grants-1977_06
Patent number
US04029704

Reaction notes

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