Potassium Carbonate → HCID 21430151, compound

HRID 437265Notes

Reaction equation

HRID 437265 reaction equation
[CH2:1]([C:8]([C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][C:11]=1[OH:17])=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18](Br)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH:25]([CH3:27])[CH3:26].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:1]([C:8]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH:25]([CH3:27])[CH3:26])=[CH:12][C:11]=1[OH:17])=[O:9])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 138005Benzyl 2,4-dihydroxyphenyl ketoneHCID 143129061-Bromo-8-methylnonane

Product 1

HCID 21430151HCID 21430151, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 22.8 parts of 2,4-dihydroxyphenyl benzyl ketone, 22.1 parts of isodecyl bromide, 27.6 g. anhydrous potassium carbonate and 250 parts of dry acetone was stirred under reflux for 3 days. After cooling and filtering the filtrates were evaporated to dryness, the residue dissolved in petrol ether and the solution filtered. The filtrates well washed with 4 × 50 parts of N sodium hydroxide solution followed by 5 × 100 parts of water. The dried petrol solution was evaporated to give 26.2 parts of 2-hydroxy-4-isodecyloxyphenyl benzyl ketone as a dark, viscous oil.

Workup

  1. temperatureunder reflux for 3 days
  2. temperatureAfter cooling
  3. filtrationfiltering the filtrates
  4. customwere evaporated to dryness
  5. dissolutionthe residue dissolved in petrol ether
  6. filtrationthe solution filtered
  7. washThe filtrates well washed with 4 × 50 parts of N sodium hydroxide solution
  8. customThe dried petrol solution was evaporated

Sources & evidence

ORD record
ord-a73e505d22b249458f133e535715f12c
Source dataset
uspto-grants-1977_06
Patent number
US04029704

Reaction notes

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