Benzyl Isothiocyanate → HCID 21427819, compound

HRID 437295Notes

Reaction equation

HRID 437295 reaction equation
[CH:1]([NH:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)=[O:2].[CH2:12]([N:19]=[C:20]=[S:21])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(O)C>[CH2:12]([NH:19][C:20](=[S:21])[NH:11][C:8]1[CH:9]=[CH:10][C:5]([NH:4][NH:3][CH:1]=[O:2])=[CH:6][CH:7]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 2346Benzyl IsothiocyanateHCID 113189Hydrazinecarboxaldehyde, 2-(4-aminophenyl)-

Product 1

HCID 21427819HCID 21427819, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Formyl-2-(4-aminophenyl)hydrazine (1.51 g, 0.01 mole) and benzyl isothiocyanate (1.49 g. p. 0.01 mole) were mixed in ethanol (30 ml) and the mixture was refluxed for 20 minutes. The product separated from solution as a white solid. The reaction mixture was chilled in ice and the solid was collected by filtration. The product was washed thoroughly with ether and then was dried. Yield 2.5 g (83%), m.p. 152°-154° C.

Workup

  1. temperaturethe mixture was refluxed for 20 minutes
  2. customThe product separated from solution as a white solid
  3. temperatureThe reaction mixture was chilled in ice
  4. filtrationthe solid was collected by filtration
  5. washThe product was washed thoroughly with ether
  6. customwas dried

Sources & evidence

ORD record
ord-466d864cfb3a4a85862d7af5ba25f7cf
Source dataset
uspto-grants-1977_06
Patent number
US04030925

Reaction notes

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