Nitric Acid → HCID 54711103, compound

HRID 437365Notes

Reaction equation

HRID 437365 reaction equation
[CH2:1]([N:3]1[C:13]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=2[C:7]([OH:14])=[CH:6][C:4]1=[O:5])[CH3:2].[N+:15]([O-])([OH:17])=[O:16]>C(O)(=O)C>[CH2:1]([N:3]1[C:13]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=2[C:7]([OH:14])=[C:6]([N+:15]([O-:17])=[O:16])[C:4]1=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 54711092HCID 54711092, compound

Product 1

HCID 54711103HCID 54711103, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

A suspension of 1-ethyl-4-hydroxy-5,6,7,8-tetrahydrocarbostyril (1.74 g; 0.009 mole) in glacial acetic acid (10 ml) was solubilised with concentrated nitric acid (2.5 ml; d 1.42) and the mixture heated for a few minutes at 100° C. After cooling and dilution with water a yellow crystalline solid separated. On recrystallisation from ethanol it had m.p. 152°- 154° C (d).

Workup

  1. temperatureAfter cooling
  2. customdilution with water a yellow crystalline solid separated
  3. customOn recrystallisation from ethanol it

Sources & evidence

ORD record
ord-78fb1970f3594e1fb004854afe4ea621
Source dataset
uspto-grants-1977_06
Patent number
US04031099

Reaction notes

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