反应详情

A stirred solution of 460 g. of cis-2,6-dimethylpiperidine in 300 ml. of xylene is treated with 278 g. of 3-bromopropanol over a period of 15 minutes. The mixture is stirred and heated at reflux for 2 hours, then allowed to cool while stirring for 16 hours. The mixture is filtered and the filtrate evaporated at reduced pressure. The residue is distilled at reduced pressure to give cis-2,6-dimethyl-1-piperidinepropanol; b.p. 147°-149° C./25 mm.

1. temperatureheated
2. temperatureat reflux for 2 hours
3. temperatureto cool
4. stirringwhile stirring for 16 hours
5. filtrationThe mixture is filtered
6. customthe filtrate evaporated at reduced pressure
7. distillationThe residue is distilled at reduced pressure