2,6-Diaminopyridine → 5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-amine

HRID 437390Notes

Reaction equation

HRID 437390 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH2:8])[N:3]=1.[CH2:9]([C:16]([C:18]([F:21])([F:20])[F:19])=O)[C:10]([C:12]([F:15])([F:14])[F:13])=O>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]2[C:4](=[N:8][C:10]([C:12]([F:13])([F:14])[F:15])=[CH:9][C:16]=2[C:18]([F:19])([F:21])[F:20])[N:3]=1

Participants

3

Reactant 2

HCID 88612,6-DiaminopyridineHCID 73706Hexafluoroacetylacetone

Product 1

HCID 27830715,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-amine

Procedure

A process as claimed in claim 1 wherein 2,6-diaminopyridine is reacted with 1,1,1,5,5,5-hexafluoroacetylacetone to provide 2-amino-5,7-di(trifluoromethyl)-1,8-naphthyridine.

Sources & evidence

ORD record
ord-9783d5eaa771445ab36ce86c1e0c6c74
Source dataset
uspto-grants-1977_06
Patent number
US04031103

Reaction notes

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