HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5,6-Dichloro-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 20359968 | HCID 20359968 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5,6-Dichloro-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridine | HCID 21556971 | — |
Reaction Steps
1-(Methylcarbamoyloxy)-6-chloro-2-(trifluoromethyl) -1H-imidazo [4,5-b] pyridine (250 milligrams) in 2.5milliliters of methanol was saturated with HCl. The reaction mixture was permitted to stand for three hours, then poured into water and filtered to separate the desired 5,6-dichloro-2-(trifluoromethyl)-1H-imidazo[ 4,5-b] pyridine, m.p., 280° -30° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04031107 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-84823d8a2ae84ed3b32c01ada3b536a3 |
| Source note | uspto-grants-1977_06 |