Hydrochloric Acid → 5,6-Dichloro-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridine

HRID 437397Notes

Reaction equation

HRID 437397 reaction equation
CNC(O[N:6]1[C:14]2[C:9](=[N:10][CH:11]=[C:12]([Cl:15])[CH:13]=2)[N:8]=[C:7]1[C:16]([F:19])([F:18])[F:17])=O.[ClH:20].O>CO>[Cl:20][C:11]1[N:10]=[C:9]2[N:8]=[C:7]([C:16]([F:19])([F:18])[F:17])[NH:6][C:14]2=[CH:13][C:12]=1[Cl:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 20359968HCID 20359968, compound

Product 1

HCID 215569715,6-Dichloro-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(Methylcarbamoyloxy)-6-chloro-2-(trifluoromethyl) -1H-imidazo [4,5-b] pyridine (250 milligrams) in 2.5milliliters of methanol was saturated with HCl. The reaction mixture was permitted to stand for three hours, then poured into water and filtered to separate the desired 5,6-dichloro-2-(trifluoromethyl)-1H-imidazo[ 4,5-b] pyridine, m.p., 280° -30° C.

Workup

  1. filtrationfiltered
  2. customto separate the desired 5,6-dichloro-2-(trifluoromethyl)-1H-imidazo[ 4,5-b] pyridine, m.p., 280° -30° C.

Sources & evidence

ORD record
ord-84823d8a2ae84ed3b32c01ada3b536a3
Source dataset
uspto-grants-1977_06
Patent number
US04031107

Reaction notes

Loading…