Hydrogen Bromide → 5,6-Dichloro-2-trifluoromethylbenzimidazole

HRID 437400Notes

Reaction equation

HRID 437400 reaction equation
Br.CNC(O[N:7]1[C:11]2[CH:12]=[C:13]([Cl:17])[C:14]([Cl:16])=[CH:15][C:10]=2[N:9]=[C:8]1[C:18]([F:21])([F:20])[F:19])=O>CO>[Cl:17][C:13]1[C:14]([Cl:16])=[CH:15][C:10]2[N:9]=[C:8]([C:18]([F:21])([F:19])[F:20])[NH:7][C:11]=2[CH:12]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 54300085HCID 54300085, compound

Product 1

HCID 168595,6-Dichloro-2-trifluoromethylbenzimidazole

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

HBr was passed into a cooled (0° -5° C.) solution of 1.05 grams of 1-(methylcarbamoyloxy)-5,6-dichloro-2 -(trifluoromethyl) benzimidazole in 40 milliliters of methanol. The reaction mixture was permitted to stand for twenty minutes, then evaporated to obtain as a residue 5,6-dichloro-2-(trifluoromethyl) benzimidazole. After recrystallization from chloroform, it melted at 233° -5° C.

Workup

  1. waitto stand for twenty minutes
  2. customevaporated

Sources & evidence

ORD record
ord-eeb65c7767474d69a2639dbd568ffe22
Source dataset
uspto-grants-1977_06
Patent number
US04031107

Reaction notes

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