HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Carboxy-2-(2-propoxyphenyl)pyrimidin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ethyl 1,6-dihydro-6-oxo-2-(2-propoxyphenyl)pyrimidine-5-carboxylate | HCID 12535801 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 5-Carboxy-2-(2-propoxyphenyl)pyrimidin-4(3H)-one | HCID 12535844 | 97.4% |
Reaction Steps
A solution of ethyl 1,6-dihydro-6-oxo-2-(2-n-propoxyphenyl)pyrimidine-5-carboxylate (3.02 g., 0.01 mole) in 1N sodium hydroxide (22 ml.) was heated on a steam bath for 20 minutes. The cooled solution was treated with 1N hydrochloric acid (23 ml.). The precipitated 1,6-dihydro-6-oxo-2-(2-n-propoxyphenyl)pyrimidine-5-carboxylic acid (2.67 g., 97.4% yield), m.p. 203°-206°, was recrystallized from ethanol to give product with m.p. 205.5°-207.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04031093 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-b1129ed326ee4bd8975bb5d8a0a8e270 |
| Source note | uspto-grants-1977_06 |