反应详情

A solution of ethyl 1,6-dihydro-6-oxo-2-(2-n-propoxyphenyl)pyrimidine-5-carboxylate (3.02 g., 0.01 mole) in 1N sodium hydroxide (22 ml.) was heated on a steam bath for 20 minutes. The cooled solution was treated with 1N hydrochloric acid (23 ml.). The precipitated 1,6-dihydro-6-oxo-2-(2-n-propoxyphenyl)pyrimidine-5-carboxylic acid (2.67 g., 97.4% yield), m.p. 203°-206°, was recrystallized from ethanol to give product with m.p. 205.5°-207.5°.