4-Methoxyphenyl isothiocyanate → 1-[4-(2-Formylhydrazino)-3-methoxyphenyl]-3-(4-methoxyphenyl)thiourea

HRID 437519Notes

Reaction equation

HRID 437519 reaction equation
[CH:1]([NH:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][C:6]=1[O:12][CH3:13])=[O:2].[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]=[C:23]=[S:24])=[CH:18][CH:17]=1>>[CH:1]([NH:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:23]([NH:22][C:19]2[CH:20]=[CH:21][C:16]([O:15][CH3:14])=[CH:17][CH:18]=2)=[S:24])=[CH:7][C:6]=1[O:12][CH3:13])=[O:2]

Participants

3

Reactant 2

HCID 752934-Methoxyphenyl isothiocyanateHCID 214278421-Formyl-2-(4-amino-2-methoxyphenyl)hydrazine

Product 1

HCID 214278471-[4-(2-Formylhydrazino)-3-methoxyphenyl]-3-(4-methoxyphenyl)thiourea

Procedure

Procedure (18.) was employed with 1-formyl-2-(4-amino-2-methoxyphenyl)hydrazine (1.2g, 0.006 mole) and 4-methoxyphenyl isothiocyanate (1.1 g, 0.0066 mole). Yield 1.6 g (70%), m.p. 160°-162° C.

Sources & evidence

ORD record
ord-49c494145d5245c2a7a3ab8cbc19ee90
Source dataset
uspto-grants-1977_06
Patent number
US04031127

Reaction notes

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