Ethyl Acetate → HCID 11148694, compound

HRID 437520Notes

Reaction equation

HRID 437520 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][NH:11][C:12](=[O:17])[C:13]([F:16])([F:15])[F:14])=[CH:6][CH:5]=1)([O-])=O.C(OCC)(=O)C.[H][H]>C(O)C.[Pt]=O>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([NH:10][NH:11][C:12](=[O:17])[C:13]([F:14])([F:15])[F:16])=[CH:8][CH:9]=1

Participants

6

Reactant 3

HCID 8857Ethyl AcetateHCID 31126762,2,2-trifluoro-N'-(4-nitrophenyl)acetohydrazideHCID 178418361HCID 178418361, compound

Product 1

HCID 11148694HCID 11148694, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

2-(4-Nitrophenyl)-1-trifluoroacetylhydrazine (2.5 g, 0.01 mole) and platinum oxide (84%, catalytic amount) were mixed in ethanol (100 ml) and ethyl acetate (100 ml) in a Parr shaker bottle. The reaction mixture was hydrogenated at room temperature until hydrogen uptake ceased. The reaction mixture was filtered and the solvent was evaporated from the filtrate leaving a brown semisolid. Yield 2.0 g (91%), no m.p. was taken on this material. Spectral data verified its structure.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent was evaporated from the filtrate
  3. customleaving a brown semisolid

Sources & evidence

ORD record
ord-74e039caf05840cb80fe06a5c4baa469
Source dataset
uspto-grants-1977_06
Patent number
US04031127

Reaction notes

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