HCID 21428729, compound → 3-(4-Methylphenoxy)piperidine

HRID 437553Notes

Reaction equation

HRID 437553 reaction equation
C([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([O:14][C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)[CH2:9]1)C1C=CC=CC=1>[Pd].C(O)C>[C:18]1([CH3:21])[CH:17]=[CH:16][C:15]([O:14][CH:10]2[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]2)=[CH:20][CH:19]=1

Participants

4

Reactant 1

HCID 21428729HCID 21428729, compound

Product 1

HCID 214287183-(4-Methylphenoxy)piperidine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 2.9 g of 1-benzyl-3-(p-tolyloxy) piperidine in 30 ml. of 95% ethanol is added to 0.42 g of 10% Pd-C, and hydrogenated at about 50° C. for 3 hours. Then the reaction mixture is cooled to ambient temperature, the 10% Pd-C is filtered off, and the ethanol is removed leaving a yellow oil of 3-(p-tolyloxy)piperidine.

Workup

  1. filtrationthe 10% Pd-C is filtered off
  2. customthe ethanol is removed

Sources & evidence

ORD record
ord-bcc6ccc6d8834f7590a0d0ef152c2668
Source dataset
uspto-grants-1977_06
Patent number
US04031221

Reaction notes

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