Toluene → HCID 21428717, compound

HRID 437579Notes

Reaction equation

HRID 437579 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[C:31]1([O:37][C:38](Cl)=[O:39])[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1.C1(C)C=CC=CC=1>CCCCCC>[O:37]([C:38]([N:8]1[CH2:9][CH2:10][C:11]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)([O:14][C:15]2[CH:16]=[CH:17][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:19][CH:20]=2)[CH2:12][CH2:13]1)=[O:39])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

Participants

5

Reactant 3

HCID 1140TolueneHCID 15891Phenyl chloroformateHCID 214287034-Phenyl-1-(phenylmethyl)-4-[4-(trifluoromethyl)phenoxy]piperidine

Product 1

HCID 21428717HCID 21428717, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

A solution of 10.0 g of 1-benzyl-4-phenyl-4-(p-trifluoromethylphenoxy)piperidine and 4.1 g of phenylchloroformate in 100 ml. of toluene was refluxed for 17 hours. The toluene was removed under reduced pressure to give a colorless oil which when rubbed with a glass rod in the presence of hexane gave a white solid of 1-phenoxycarbonyl-4-phenyl-4-(p-trifluoromethylphenoxy)piperidine.

Workup

  1. customThe toluene was removed under reduced pressure
  2. customto give a colorless oil which when

Sources & evidence

ORD record
ord-bdcd67b513d74288afbc06b08fb64a16
Source dataset
uspto-grants-1977_06
Patent number
US04031221

Reaction notes

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