1-Bromohexane → HCID 21428688, compound

HRID 437590Notes

Reaction equation

[CH3:1][C:2]1([CH3:35])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[O:12])[N:4]([CH2:13][CH2:14][CH2:15][NH:16][CH2:17][CH2:18][CH2:19][N:20]2[C:29](=[O:30])[C:28]([CH3:32])([CH3:31])[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:21]2=[O:33])[C:3]1=[O:34].[CH2:36](Br)[CH2:37][CH2:38][CH2:39][CH2:40][CH3:41].C([O-])(=O)/C=C/C([O-])=O>>[CH3:32][C:28]1([CH3:31])[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:21](=[O:33])[N:20]([CH2:19][CH2:18][CH2:17][N:16]([CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])[CH2:15][CH2:14][CH2:13][N:4]2[C:3](=[O:34])[C:2]([CH3:35])([CH3:1])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]2=[O:12])[C:29]1=[O:30]

Participants

Reactant 3

HCID 81011-Bromohexane

HCID 5460307Fumarate

HCID 6454458AR 03 Cl

Product 1

HCID 21428688HCID 21428688, compound

Procedure

N,N-Bis-[3-(3,4-dihydro-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolyl)-propyl]-n-hexylamine was prepared analogous to Example 27 from 2.6 gm of N,N-bis-[3-(3,4-dihydro-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolyl)-propyl]-amine and 1 gm of n-hexyl bromide. M.p. of the fumarate: 137°-138° C; yield: 1.7 gm (50% of theory).

Workup

custom137°-138° C

Sources & evidence

ORD record: ord-c487c80e30924ff7b23fab91768c2bb6
Source dataset: uspto-grants-1977_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04031219

Reaction notes

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