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温度

0 °C

To a mixture of 21.6 parts of aziridine and 37.8 parts of sodium hydrogen carbonate is added dropwise a solution of 85 parts of 4-fluoro-2-nitro benzoyl chloride in 75 parts of trichloromethane while stirring vigorously at 0° C. Upon completion, stirring vigorously is continued for 30 minutes without cooling. After warming to 25° C, the reaction mixture is adjusted to pH 8 with a diluted sodium hydroxide solution. The product is extracted three times with trichloromethane. The combined extracts are washed with water, dried filtered and evaporated, yielding 75 parts of 1-(4-fluoro-2-nitrobenzoyl)aziridine as a residue.

1. stirringUpon completion, stirring vigorously
2. temperaturewithout cooling
3. temperatureAfter warming to 25° C
4. extractionThe product is extracted three times with trichloromethane
5. washThe combined extracts are washed with water
6. customdried
7. filtrationfiltered
8. customevaporated