反应详情

A mixture of 12.94 parts of ethyl (2-bromoethyl)carbamate, 13.51 parts of 1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one, 10.1 parts of sodium hydrogen carbonate and 160 parts of ethanol is stirred and refluxed overnight. The reaction mixture is cooled, filtered over hyflo and the filtrate is evaporated. The residue is purified by column-chromatography over silica gel using a mixture of trichloromethane, 10% of methanol and one drop of ammonium hydroxide, as eluent. The pure fractions are collected and the eluent is evaporated, yielding 4.4 parts of ethyl 2-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethylcarbamate as a residue.

1. temperaturerefluxed overnight
2. temperatureThe reaction mixture is cooled
3. filtrationfiltered over hyflo
4. customthe filtrate is evaporated
5. customThe residue is purified by column-chromatography over silica gel using
6. additiona mixture of trichloromethane, 10% of methanol and one drop of ammonium hydroxide
7. customThe pure fractions are collected
8. customthe eluent is evaporated