HRID437644

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8028

Tetrahydrofuran

C4H8O

结构：Cl.O=C(NCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1[N+](=O)[O-]

HCID21428974

未命名化合物

HCID178418361

未命名化合物

PRODUCTS

生成物

结构：Cl.Cl.Cl.Cl.Nc1ccccc1C(=O)NCCN1CCC(O)(c2ccc(Cl)cc2)CC1.Nc1ccccc1C(=O)NCCN1CCC(O)(c2ccc(Cl)cc2)CC1.O

HCID131710822

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A mixture of 3.5 parts of N-{2-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]ethyl}-2-nitrobenzamide hydrochloride, 90 parts of tetrahydrofuran and 40 parts of methanol is hydrogenerated at normal pressure and at room temperature with 0.2 parts of platinium dioxide. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. The residue is converted into the hydrochloride salt in 2-propanol and 2,2'-oxybispropane. The salt is filtered off and dried, yielding 2.6 parts of 2-amino-N-{2-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]ethyl}benzamide dihydrochloride hemihydrate; mp. 195.7° C.

WORKUP

后处理

filtrationthe catalyst is filtered off
customthe filtrate is evaporated
filtrationThe salt is filtered off
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4b49f81c3aa9442a80c61ba2679973a1
来源数据集: uspto-grants-1977_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04031226
来源说明: uspto-grants-1977_06

反应 SMILES

[ClH:1].[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([OH:29])[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH:17][C:18](=[O:28])[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[N+:25]([O-])=[O:26])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.O1CCCC1.[H][H]>CO>[OH2:26].[ClH:2].[ClH:1].[NH2:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[C:18]([NH:17][CH2:16][CH2:15][N:12]1[CH2:13][CH2:14][C:9]([C:6]2[CH:5]=[CH:4][C:3]([Cl:2])=[CH:8][CH:7]=2)([OH:29])[CH2:10][CH2:11]1)=[O:28].[NH2:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[C:18]([NH:17][CH2:16][CH2:15][N:12]1[CH2:13][CH2:14][C:9]([OH:29])([C:6]2[CH:5]=[CH:4][C:3]([Cl:2])=[CH:8][CH:7]=2)[CH2:10][CH2:11]1)=[O:28].[ClH:2].[ClH:2]