反应详情

A mixture of 6.6 parts of ethyl {2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl }-carbamate, 60 parts of a hydrobromic acid solution 48% in water and 4 parts of water is stirred and refluxed for 2.50 hours. After cooling, the precipitated product is filtered off and crystallized from water, yielding 5.5 parts of 1- [1-(2-aminoethyl)-4-piperidinyl]-5-chloro-1,3-dihydro-2H-benzimidazol-2-one dihydrobromide; mp. > 300° C.

1. temperaturerefluxed for 2.50 hours
2. temperatureAfter cooling
3. filtrationthe precipitated product is filtered off
4. customcrystallized from water