反应详情

A mixture of 3.64 parts of methyl {2,3-dihydro-1-[1-(phenylmethyl)-4-piperidinyl]-1H-benzimidazol-2-ylidene}carbamate, 24 parts of a hydrochloric acid solution and 40 parts of ethanol is stirred and refluxed overnight. The reaction mixture is evaporated and the residue is dissolved in water. This solution is alkalized with a concentrated ammonium hydroxide solution. The precipitated product is filtered off, washed with water and dissolved in trichloromethane. The solution is dried, filtered and evaporated, yielding 2.1 parts of 1-[1-(phenylmethyl)-4-piperidinyl]-1H-benzimidazol-2-amine as a residue.

1. temperaturerefluxed overnight
2. customThe reaction mixture is evaporated
3. dissolutionthe residue is dissolved in water
4. filtrationThe precipitated product is filtered off
5. washwashed with water
6. dissolutiondissolved in trichloromethane
7. customThe solution is dried
8. filtrationfiltered
9. customevaporated