Ethyl [4-(Benzyloxy)phenoxy]acetate → Ethyl 2-(4-hydroxyphenoxy)acetate

HRID 437687Notes

Reaction equation

HRID 437687 reaction equation
C([O:8][C:9]1[CH:21]=[CH:20][C:12]([O:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd].C(O)C>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:20][CH:21]=1

Participants

4

Reactant 1

HCID 734886Ethyl [4-(Benzyloxy)phenoxy]acetate

Product 1

HCID 13187337Ethyl 2-(4-hydroxyphenoxy)acetate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

EThyl 4-benzyloxyphenoxyacetate (5.8 g.) was hydrogenated in the presence of 0.5 g. of palladium-on-carbon catalyst in 200 ml. of absolute ethanol. There was obtained 4.00 g. of ethyl 4-hydroxyphenoxyacetate, m.p. 124°-125° C. when recrystallized from isopropyl alcohol.

Workup

  1. customThere was obtained 4.00 g
  2. customof ethyl 4-hydroxyphenoxyacetate, m.p. 124°-125° C. when recrystallized from isopropyl alcohol

Sources & evidence

ORD record
ord-484cb848ac3c41708af8cb88f881b814
Source dataset
uspto-grants-1977_06
Patent number
US04031246

Reaction notes

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