反应详情

The methyl ester of Example 10, 300 mg., is dissolved in 100 ml. of methanol saturated with ammonia and kept for 4 days at room temperature. The crude product is chromatographed on silica gel in chloroform-methanol-water (60:30:5) to yield 0.14 g.; m.p. 180°-185° C.

1. dissolution, is dissolved in 100 ml
2. customThe crude product is chromatographed on silica gel in chloroform-methanol-water (60:30:5)
3. customto yield 0.14 g