HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Nalpha-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-D-tyrosyl-D-alaninamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Nalpha-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-D-tyrosyl-D-alanine methyl ester | HCID 54340573 | — |
| Product | Nalpha-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-D-tyrosyl-D-alaninamide | HCID 53958670 | — |
Reaction Steps
The methyl ester of Example 10, 300 mg., is dissolved in 100 ml. of methanol saturated with ammonia and kept for 4 days at room temperature. The crude product is chromatographed on silica gel in chloroform-methanol-water (60:30:5) to yield 0.14 g.; m.p. 180°-185° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04031069 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-616a712368e2403da4f290160e8397c0 |
| Source note | uspto-grants-1977_06 |