Isopropylamine → HCID 17180494, compound

HRID 437720Notes

Reaction equation

HRID 437720 reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].[CH2:5]([O:7][C:8]([C:10]1[C:11]([CH3:25])=[N:12][S:13][C:14]=1[NH:15][C:16]([O:18]C1C=CC=CC=1)=O)=[O:9])[CH3:6]>C(O)C>[CH2:5]([O:7][C:8]([C:10]1[C:11]([CH3:25])=[N:12][S:13][C:14]=1[NH:15][C:16]([NH:4][CH:1]([CH3:3])[CH3:2])=[O:18])=[O:9])[CH3:6]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 2820507HCID 2820507, compound

Product 1

HCID 17180494HCID 17180494, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of isopropylamine in ethanol (33% w/v; 30 ml.) was added, cautiously with swirling, to 4-ethoxycarbonyl-3-methyl-5-phenoxycarbonylaminoisothiazole (prepared according to the method of Goerdeler and Horn, Chemische Berichte, 1963, 96, 1551; 30 g.). When the initial exothermic reaction had subsided the mixture was heated at reflux for 10 minutes, cooled and filtered. The solid was washed with water, and dried to give 1-(4-ethoxycarbonyl-3-methylisothiazol-5-yl)-3-isopropylurea (20.8 g.), m.p. 175°-176° C.

Workup

  1. customprepared
  2. customWhen the initial exothermic reaction
  3. temperaturewas heated
  4. temperatureat reflux for 10 minutes
  5. temperaturecooled
  6. filtrationfiltered
  7. washThe solid was washed with water
  8. customdried

Sources & evidence

ORD record
ord-49f02e05574d4a3789b4e29ebc2fcd2a
Source dataset
uspto-grants-1977_06
Patent number
US04032323

Reaction notes

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