Isopropylamine → HCID 17180494, compound

Participants

Reaction Steps

A solution of isopropylamine in ethanol (33% w/v; 30 ml.) was added, cautiously with swirling, to 4-ethoxycarbonyl-3-methyl-5-phenoxycarbonylaminoisothiazole (prepared according to the method of Goerdeler and Horn, Chemische Berichte, 1963, 96, 1551; 30 g.). When the initial exothermic reaction had subsided the mixture was heated at reflux for 10 minutes, cooled and filtered. The solid was washed with water, and dried to give 1-(4-ethoxycarbonyl-3-methylisothiazol-5-yl)-3-isopropylurea (20.8 g.), m.p. 175°-176° C.

Provenance & Evidence