Methylamine → HCID 21426793, compound

HRID 437730Notes

Reaction equation

HRID 437730 reaction equation
Br.[CH2:2]([O:4][C:5]([C:7]1[C:8]([CH2:22][CH2:23][CH3:24])=[N:9][S:10][C:11]=1[NH:12][C:13]([O:15]C1C=CC=CC=1)=O)=[O:6])[CH3:3].[CH3:25][NH2:26]>>[CH2:2]([O:4][C:5]([C:7]1[C:8]([CH2:22][CH2:23][CH3:24])=[N:9][S:10][C:11]=1[NH:12][C:13]([NH:26][CH3:25])=[O:15])=[O:6])[CH3:3]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 21426782HCID 21426782, compound

Product 1

HCID 21426793HCID 21426793, compound

Procedure

4-Ethoxycarbonyl-5-phenoxycarbonylamino-3-n-propylisothiazol hydrobromide (41.5 g.) was heated at reflux in ethanolic methylamine (33% w/v; 100 ml.) for 15 minutes. The solution was filtered and on cooling deposited white crystals, which were filtered off and washed with water to give 1-(4-ethoxycarbonyl-3-n-propylisothiazol-5-yl)-3-methylurea (18.5 g.), m.p. 173°-174° C.

Workup

  1. filtrationThe solution was filtered
  2. temperatureon cooling
  3. filtrationwere filtered off
  4. washwashed with water

Sources & evidence

ORD record
ord-99e64528f5474fd2b854efb0d6c363aa
Source dataset
uspto-grants-1977_06
Patent number
US04032323

Reaction notes

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