HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 5-Methylthiopyrano[3,2-b]indol-4(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Thiopyrano[3,2-b]indol-4(5H)-one | HCID 20326608 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 5-Methylthiopyrano[3,2-b]indol-4(5H)-one | HCID 20326611 | — |
Reaction Steps
Sodium hydride (2.3 g of 50% suspension in mineral oil, 0.05 mole) is washed with hexane and suspended in 25 ml of dimethylformamide (DMF). Thiopyrano [3,2-b]indol-4(5H)-one, 10.0 g (0.05 mole) in 130 ml of DMF is added and the mixture stirred for 3 hours. Methyl iodide (14.2 g, 0.1 mole) is added and the mixture stirred for 3 hours and then poured over ice. The white precipitate is filtered, dried and recrystallized from hexane to give 9.3 g of product, mp 113°-114° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04032537 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-630c046baf5e43b3a726f81d98b399ca |
| Source note | uspto-grants-1977_06 |