3-Chloro-1-propanol → 3-{4-[2-Chloro10,11-dihydro-dibenz[b,f]oxepin-10-yl]-1-piperazinyl}-1-propanol

HRID 437820Notes

Reaction equation

HRID 437820 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][C:7]3[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=3[CH:9]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[CH2:10][C:4]=2[CH:3]=1.Cl[CH2:24][CH2:25][CH2:26][OH:27]>>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][C:7]3[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=3[CH:9]([N:11]3[CH2:12][CH2:13][N:14]([CH2:24][CH2:25][CH2:26][OH:27])[CH2:15][CH2:16]3)[CH2:10][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 123133-Chloro-1-propanolHCID 227679431-[2-Chloro-10,11-dihydro-dibenz[b,f]oxepin-10-yl]-piperazine

Product 1

HCID 203151243-{4-[2-Chloro10,11-dihydro-dibenz[b,f]oxepin-10-yl]-1-piperazinyl}-1-propanol

Procedure

In an analogous manner to that described in Example 5, from 1-[2-chloro-10,11-dihydro-dibenz[b,f]oxepin-10-yl]-piperazine and 3-chloro-1-propanol, there is obtained 3-{4-[2-chloro10,11-dihydro-dibenz[b,f]oxepin-10-yl]-1-piperazinyl}-1-propanol as an oil. The dihydrochloride, prepared in ethanol, melts at 206°-207° C. (with decomposition).

Sources & evidence

ORD record
ord-9c9a5bcc842c4d35a8608f495544ab0b
Source dataset
uspto-grants-1977_06
Patent number
US04032525

Reaction notes

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