HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpiperidine → 3-(cyanoimino)-3-(N,N-diethylamino)propionitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpiperidine | HCID 7974 | — |
| Reactant | Ethanimidic acid, N,2-dicyano-, ethyl ester | HCID 12272864 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(cyanoimino)-3-(N,N-diethylamino)propionitrile | HCID 12436752 | — |
Reaction Steps
A solution of 4.00 g (0.0292 m) of ethyl N,2-dicyanoacetimidate and 2.86 g (0.0292 m) 2-methylpiperidine in 80 ml of tetrahydrofuran is stirred for five days at room temperature. The reaction product is isolated in the same way as 3-(cyanoimino)-3-(N,N-diethylamino)propionitrile to give 0.76 g of product, 14%. This product is further purified by chromatography on a Merck "B" column to give material whose nmr, ir, and mass spec are consistent with the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04032559 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-3262dec5736b4b7fa2ee8654b70addf2 |
| Source note | uspto-grants-1977_06 |