2-Methylpiperidine → 3-(cyanoimino)-3-(N,N-diethylamino)propionitrile
Reaction equation
[C:1]([N:3]=[C:4](OCC)[CH2:5][C:6]#[N:7])#[N:2].[CH3:11][CH:12]1CC[CH2:15][CH2:14][NH:13]1>O1CCCC1>[C:1]([N:3]=[C:4]([N:13]([CH2:14][CH3:15])[CH2:12][CH3:11])[CH2:5][C:6]#[N:7])#[N:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 4.00 g (0.0292 m) of ethyl N,2-dicyanoacetimidate and 2.86 g (0.0292 m) 2-methylpiperidine in 80 ml of tetrahydrofuran is stirred for five days at room temperature. The reaction product is isolated in the same way as 3-(cyanoimino)-3-(N,N-diethylamino)propionitrile to give 0.76 g of product, 14%. This product is further purified by chromatography on a Merck "B" column to give material whose nmr, ir, and mass spec are consistent with the desired product.
Sources & evidence
- ORD record
- ord-3262dec5736b4b7fa2ee8654b70addf2
- Source dataset
- uspto-grants-1977_06
- Patent number
- US04032559
Reaction notes
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