Water → HCID 21427307, compound

HRID 437916Notes

Reaction equation

HRID 437916 reaction equation
[CH3:1][NH:2][C:3](=[O:22])[CH2:4][CH2:5][NH:6][C:7](=[O:21])[C:8]1[C:13]([I:14])=[C:12]([NH2:15])[C:11]([I:16])=[C:10]([C:17]([OH:19])=[O:18])[C:9]=1[I:20].O.[C:24](Cl)(=[O:26])[CH3:25]>CC(N(C)C)=O>[CH3:1][NH:2][C:3](=[O:22])[CH2:4][CH2:5][NH:6][C:7](=[O:21])[C:8]1[C:13]([I:14])=[C:12]([NH:15][C:24](=[O:26])[CH3:25])[C:11]([I:16])=[C:10]([C:17]([OH:19])=[O:18])[C:9]=1[I:20]

Participants

5

Reactant 3

HCID 962WaterHCID 6367Acetyl chlorideHCID 21427284HCID 21427284, compound

Product 1

HCID 21427307HCID 21427307, compoundYield 58.8%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

99.5 g. (0.15 mole) of N-(3-carboxy-5-amino-2,4,6-triiodobenzoyl)-β -alanine methylamide . 1.1 H2O (IVf), m.p. 250°-252° C. (decomposition) in 190 ml. of dimethylacetamide yield, after reaction with 40.0 ml. of acetyl chloride analogously to Example 1, 60.4 g. (58.8%) of the desired compound. A sample for analysis is purified in alcohol by way of the dimethylammonium salt; m.p. 288°-289° C. (under decomposition).

Workup

  1. customafter reaction with 40.0 ml

Sources & evidence

ORD record
ord-cb75584c03c244c2afc15c2a70e5acff
Source dataset
uspto-grants-1977_06
Patent number
US04032567

Reaction notes

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