HCID 131730871, compound → Ethyl cis(+/-)-2-(4-amino-3-methoxypiperidin-1-yl)-5-methylpyridine-4-carboxylate

HRID 43792Notes

Reaction equation

HRID 43792 reaction equation
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:21]([CH3:29])=[CH:20][N:19]=2)[CH2:14][C@H:13]1[O:30][CH3:31])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:21]([CH3:29])=[CH:20][N:19]=2)[CH2:14][C@H:13]1[O:30][CH3:31]

Participants

3

Reactant 1

HCID 131730871HCID 131730871, compound

Product 1

HCID 86648743Ethyl cis(+/-)-2-(4-amino-3-methoxypiperidin-1-yl)-5-methylpyridine-4-carboxylateYield 18.5%

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

The same operation as in Example (160c) was performed using ethyl cis(±)-2-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-methylpyridine-4-carboxylate obtained in Example (180a) (207 mg, 0.48 mmol) and a 10% palladium-carbon catalyst (200 mg), to obtain 26.1 mg of the title compound as a yellow oily substance.

Sources & evidence

ORD record
ord-9536d1429b49410b87d09dda64ceb9ae
Source dataset
uspto-grants-2013_09
Patent number
US08536197B2

Reaction notes

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