p-Toluenesulfonic acid → HCID 23334290, compound

HRID 437959Notes

Reaction equation

HRID 437959 reaction equation
C([O:3][C:4](=O)[C:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[C:6]([NH2:10])OCC)C.C1(C)C=CC(S(O)(=O)=O)=CC=1.[F:29][C:30]([F:42])([F:41])[C:31]1[CH:32]=[C:33]([CH:37]=[CH:38][C:39]=1[CH3:40])[CH2:34][NH:35][NH2:36]>C(O)C>[NH2:10][C:6]1[NH:36][N:35]([CH2:34][C:33]2[CH:37]=[CH:38][C:39]([CH3:40])=[C:31]([C:30]([F:41])([F:42])[F:29])[CH:32]=2)[C:4](=[O:3])[C:5]=1[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 23334287HCID 23334287, compoundHCID 70587485HCID 70587485, compound

Product 1

HCID 23334290HCID 23334290, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 35.3 g α-phenyl-β-amino-β-ethoxyacrylic acid ethyl ester and 1 g p-toluenesulphonic acid in 150 ml ethanol were added dropwise, under nitrogen, 31.5 g 3-trifluoromethyl-4-methylbenzylhydrazine. After stirring overnight, the solvent was distilled off in a vacuum; the residue was recrystallized from dimethyl formamide.

Workup

  1. distillationthe solvent was distilled off in a vacuum
  2. customthe residue was recrystallized from dimethyl formamide

Sources & evidence

ORD record
ord-a32bfd720f6347e4b196e54d7e7021d8
Source dataset
uspto-grants-1977_06
Patent number
US04032646

Reaction notes

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