Formaldehyde → HCID 54458627, compound

HRID 438026Notes

Reaction equation

HRID 438026 reaction equation
[P:1]([O:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[O:2]C1C=CC=CC=1.[CH2:23]=O.[CH3:25][C:26]1[CH:27]=[CH:28][C:29]([S:32]([NH2:35])(=[O:34])=[O:33])=[CH:30][CH:31]=1>ClC1C=CC=CC=1>[C:26]1([CH3:25])[CH:27]=[CH:28][C:29]([S:32]([NH:35][CH2:23][P:1](=[O:2])([O:9][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[O:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)(=[O:34])=[O:33])=[CH:30][CH:31]=1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 6269P-ToluenesulfonamideHCID 7540Triphenyl phosphite

Product 1

HCID 54458627HCID 54458627, compound

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

When a mixture of 77.6 g of triphenyl phosphite, 8.2 g of paraformaldehyde, and 42.8 g of p-toluenesulfonamide in 150 g of chlorobenzene is warmed, heat of reaction is observed at about 95° C., and cooling is needed for a few minutes to keep the temperature below 105°. Warming is continued at 95°-105° for 1 hr and then the solvent and most of the by-product phenol is removed at reduced pressure.

Workup

  1. temperatureis warmed
  2. temperatureheat of reaction
  3. customis observed at about 95° C.
  4. temperaturecooling
  5. waitis needed for a few minutes
  6. customthe temperature below 105°
  7. temperatureWarming
  8. customthe solvent and most of the by-product phenol is removed at reduced pressure

Sources & evidence

ORD record
ord-0a2c7b20d03b46aa8b718358f9f690e9
Source dataset
uspto-grants-1977_06
Patent number
US04032601

Reaction notes

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