Lithium hydroxide, monohydrate → HCID 178437825, compound

HRID 43829Notes

Reaction equation

HRID 43829 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([C:9]([NH:11][C@H:12]2[CH2:17][CH2:16][C@H:15]([C:18]3[CH:19]=[C:20]([CH:26]=[CH:27][CH:28]=3)[C:21]([O:23]CC)=[O:22])[CH2:14][CH2:13]2)=[O:10])[NH:5][C:6]=1[CH2:7][CH3:8].O.[OH-].[Li+]>>[Cl:1][C:2]1[N:3]=[C:4]([C:9]([NH:11][C@H:12]2[CH2:17][CH2:16][C@H:15]([C:18]3[CH:19]=[C:20]([CH:26]=[CH:27][CH:28]=3)[C:21]([OH:23])=[O:22])[CH2:14][CH2:13]2)=[O:10])[NH:5][C:6]=1[CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 178468852HCID 178468852, compound

Product 1

HCID 178437825HCID 178437825, compoundYield 58%

Procedure

The same operation as in Example (1i) was performed using ethyl trans-3-{4-[(4-chloro-5-ethyl-1H-imidazole-2-carbonyl)amino]cyclohexyl}benzoate obtained in Example (193b) (43 mg, 0.106 mmol) and lithium hydroxide monohydrate (44 mg, 1.06 mmol), to obtain 23 mg of the title compound as a white solid (58%).

Sources & evidence

ORD record
ord-40f9be66b7124c7399589eccafc69b98
Source dataset
uspto-grants-2013_09
Patent number
US08536197B2

Reaction notes

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