反应详情

The same operation as in Example (1i) was performed using ethyl 3-{4-[(4-chloro-5-ethyl-1H-imidazole-2-carbonyl)amino]cyclohex-1-enyl)benzoate obtained in Example (195d) (150 mg, 0.373 mmol) and lithium hydroxide monohydrate (156 mg, 3.73 mmol), to obtain 28 mg of the title compound as a white solid (20%).