Phosphorus pentachloride → HCID 22465462, compound

HRID 439289Notes

Reaction equation

HRID 439289 reaction equation
[CH2:1]([NH:3][C:4]1[S:5][C:6]([C:10]([OH:12])=O)=[C:7]([CH3:9])[N:8]=1)[CH3:2].C(NC1SC(C(Cl)=O)=C(C)N=1)C.P(Cl)(Cl)(Cl)(Cl)Cl.Cl.[NH2:32][CH:33]([C:36]1[S:37][CH:38]=[CH:39][CH:40]=1)[C:34]#[N:35]>C(N(CC)CC)C>[C:34]([CH:33]([NH:32][C:10]([C:6]1[S:5][C:4]([NH:3][CH2:1][CH3:2])=[N:8][C:7]=1[CH3:9])=[O:12])[C:36]1[S:37][CH:38]=[CH:39][CH:40]=1)#[N:35]

Participants

6

Reactant 4

HCID 24819Phosphorus pentachlorideHCID 11327242-(Ethylamino)-4-methyl-1,3-thiazole-5-carboxylic acidHCID 133524562-Thiopheneacetonitrile, a-amino-, monohydrochlorideHCID 450818732-(Ethylamino)-4-methyl-1,3-thiazole-5-carbonyl chloride

Product 1

HCID 22465462HCID 22465462, compoundYield 32%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

1.2g of 2-ethylamino-4-methyl-thiazole-5-carboxylic acid was converted into 2-ethylamino-4-methyl-thiazole-5-carboxylic acid chloride using 1.3g of phosphorus pentachloride according to the same procedure as EXAMPLE 1. Then 1.1g of amino-thiophen-2-yl-acetonitrile hydrochloride and 2.5ml of triethylamine were added thereto and the reaction mixture was treated according to the same procedure as EXAMPLE 1 to obtain 0.57g (Yield 32%) of the title compound.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-b5450e7c900a4ec699651cc56c66b8ec
Source dataset
uspto-grants-1996_05
Patent number
US05514643

Reaction notes

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