HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus pentachloride → HCID 54344002, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | HCID 1132751 | HCID 1132751 | — |
| Reactant | Amino(phenyl)acetonitrile--hydrogen chloride (1/1) | HCID 2723717 | — |
| Reactant | HCID 53827267 | HCID 53827267 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 54344002 | HCID 54344002 | 39% |
Reaction Steps
1.2g of 2-benzylamino-4-methyl-thiazole-5-carboxylic acid was converted into 2-benzylamino-4-methyl-thiazole-5-carboxylic acid chloride using 1.1g of phosphorus pentachloride according to the same procedure as EXAMPLE 1. Then 0.89g of amino-phenylacetonitrile hydrochloride and 2.3ml of triethylamine were added thereto and the reaction mixture was treated according to the same procedure as EXAMPLE 1 to obtain 0.68g (Yield 39%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05514643 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-e33c1b1de13e42bbb4fc74fc7960682d |
| Source note | uspto-grants-1996_05 |