Phosphorus pentachloride → HCID 54344002, compound

HRID 439295Notes

Reaction equation

HRID 439295 reaction equation
[CH2:1]([NH:8][C:9]1[S:10][C:11]([C:15]([OH:17])=O)=[C:12]([CH3:14])[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(NC1SC(C(Cl)=O)=C(C)N=1)C1C=CC=CC=1.P(Cl)(Cl)(Cl)(Cl)Cl.Cl.[NH2:42][CH:43]([C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)[C:44]#[N:45]>C(N(CC)CC)C>[C:44]([CH:43]([NH:42][C:15]([C:11]1[S:10][C:9]([NH:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[N:13][C:12]=1[CH3:14])=[O:17])[C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)#[N:45]

Participants

6

Reactant 4

HCID 24819Phosphorus pentachlorideHCID 1132751HCID 1132751, compoundHCID 2723717Amino(phenyl)acetonitrile--hydrogen chloride (1/1)HCID 53827267HCID 53827267, compound

Product 1

HCID 54344002HCID 54344002, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

1.2g of 2-benzylamino-4-methyl-thiazole-5-carboxylic acid was converted into 2-benzylamino-4-methyl-thiazole-5-carboxylic acid chloride using 1.1g of phosphorus pentachloride according to the same procedure as EXAMPLE 1. Then 0.89g of amino-phenylacetonitrile hydrochloride and 2.3ml of triethylamine were added thereto and the reaction mixture was treated according to the same procedure as EXAMPLE 1 to obtain 0.68g (Yield 39%) of the title compound.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-e33c1b1de13e42bbb4fc74fc7960682d
Source dataset
uspto-grants-1996_05
Patent number
US05514643

Reaction notes

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