反应详情

0.72g of 2-cyclopropylamino-4-methyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide (12) was dissolved in 10ml of ethanol and then 0.63ml of triethylamine was added thereto. The reaction solution was stirred under reflux for 8 hours while introducing hydrogen sulfide gas. After removing the solvent, water was added to the residue and then the solid product which is not dissolved in water was filtered. The filtered solid product was washed with diethylether and then dried to obtain 0.70g (Yield 88%) of the title compound.

1. temperatureunder reflux for 8 hours
2. customAfter removing the solvent, water
3. additionwas added to the residue
4. dissolutionthe solid product which is not dissolved in water
5. filtrationwas filtered
6. washThe filtered solid product was washed with diethylether
7. customdried