Purine → HCID 22411330, compound

HRID 439309Notes

Reaction equation

[N:1]1[CH:9]=[C:8]2[C:4]([N:5]=[CH:6][NH:7]2)=[N:3][CH:2]=1.F[C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=1>>[N:7]1([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=2)[C:8]2[CH:9]=[N:1][CH:2]=[N:3][C:4]=2[N:5]=[CH:6]1

Participants

Reactant 2

HCID 1044Purine

HCID 9590p-Fluoronitrobenzene

Product 1

HCID 22411330HCID 22411330, compound

Procedure

Prepared from purine and 1-fluoro-4-nitrobenzene as described for Example 1, Step 1. The product precipitated from the reaction mixture as a single isomer; δ (D6 -DMSO) 8.16 (2H, d, J=9.0Hz, Ar--H), 8.48 (2H, d, J=9.0Hz, Ar--H), 9.13 (1H, s, Ar--H), 9.28 (1H, s, Ar--H), 9.39 (1H, s, Ar--H).

Workup

customThe product precipitated from the reaction mixture as a single isomer

Sources & evidence

ORD record: ord-0d0d4a8fa4e9499fad38a995907dc013
Source dataset: uspto-grants-1996_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05514682

Reaction notes

Loading…