Hydrochloric Acid → 3,5-Diamino-4-hydroxybenzoic acid dihydrochloride

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Reaction Steps

3,5-Diamino-4-hydroxybenzoic acid (2 g, 11.9 mmole) was dissolved in 6N hydrochloric acid (50 ml) and refluxed for 2 hours. The mixture was evaporated to dryness and the residue was treated with ethyl acetate (50 ml), filtered and dried to give 3,5-diamino-4-hydroxybenzoic acid dihydrochloride (2.58 g, 90%), m.p. 260°-262° C. (dec.) (lit. ref., Chemical Abstracts, 1908, 2379, m.p. 260° C. (dec)).

Provenance & Evidence